Decoding 7‑OH Tolerance: Mechanisms, Measurement, and Research Best Practices
Among alkaloids with activity at the mu‑opioid receptor, 7‑hydroxymitragynine (commonly shortened to 7‑OH) occupies a unique niche for preclinical researchers. Highly potent and often described as functionally selective, this molecule invites rigorous study of tolerance dynamics—how repeated exposure diminishes effect…